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Scientist I/II, Biophysics

Nautilus Biotechnology

Nautilus Biotechnology

San Carlos, CA, USA
Posted on Thursday, August 24, 2023
At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome – one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing deep, hard science with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines.
We are hiring for a Scientist I/II, Biophysics, to join our growing team. In this role, you will develop biophysical assays to characterize our affinity reagents and collaborating cross-functionally to incorporate these reagents in the Nautilus platform. This position will work closely with colleagues upstream in the probe development process and downstream in platform integration. This position will report to the Lead, Senior Staff Scientist, Probe Characterization, within the R&D organization and is located in San Carlos, CA.


  • Partner in the process of forming strategies, executing plans, analyzing results, and brainstorming innovative ideas to characterize affinity reagents using a range of state-of art techniques, and to develop and test mechanistic hypotheses.
  • Develop methods to determine whether candidate probes are likely to succeed within our platform and to better understand specific, off-target, and non-specific binding of affinity reagent candidates.
  • Document and present results and insights at departmental and cross-functional project team meetings.
  • Partner in the engagement of external partners to drive collaborative activities efficiently.
  • Stay up to date with the latest advancements and trends in biophysics and contribute to the intellectual environment of the organization.


  • A minimum of a PhD, or BS/MS and 8+ years of experience in biophysics, chemistry, physics, or a related biological/life science field.
  • Strong background in single molecule experiments such as FRET, enzyme kinetics, binding-unbinding, single particle tracking, lifetime, and/or polarization.
  • Experience with biochemical/biophysical techniques including, but not limited to, SPR, BLI, ITC, DSF, or fluorescent/luminescence plate-based assays, such as ELISA, ELONA, florescent microscopy.
  • Strong expertise in assay development with technical background in proteins, antibodies and affinity reagents and their biophysical characterization
  • Strong quantitative analysis, troubleshooting, and statistical analysis skills
  • Willingness to work collaboratively within a team as well as independently
  • Excellent record keeping, written and oral communication skills
  • Agile-like approach to development

Nautilus Team Culture

  • We are curious go-getters: this is a team of life-long learners who aren’t afraid to tackle the big challenges and we embrace the journey.
  • We are detail oriented: we do great science by working smart & with diligence where we learn from our trials and mistakes.
  • We are easy to work with: we want our workplace to be one where everyone can share their perspective and be treated with respect and kindness.