Invest in your career with a Madrona-funded company.

A-Alpha Bio is a biotechnology company harnessing synthetic biology and machine learning to measure, predict, and engineer protein-protein interactions. Our experimental platform, AlphaSeq, enables the rapid and quantitative measurement of millions of protein-protein binding affinities simultaneously. Our computational platform, AlphaBind, is trained on the world’s largest protein-protein interaction database and predicts binding strength from sequence. A-Alpha Bio leverages AlphaSeq and AlphaBind for in-house therapeutic programs and in partnership with leading pharmaceutical companies to inform the discovery and development of novel therapeutics. A-Alpha Bio is based in Seattle and was founded in 2017 at the University of Washington's Institute for Protein Design and Center for Synthetic Biology. To learn more, please visit: https://www.aalphabio.com/

Amperity is the Customer Data Platform that helps brands build the unified first-party customer data foundation they need to grow revenue, reduce costs, save time, and stay compliant. Our unparalleled solution creates accurate, reliable profiles by stitching together every type of rich customer data across disparate sources using patented AI and machine learning methods. Teams including Marketing, IT, and Analytics can easily use these profiles to drive business value – boosting acquisition and retention, discovering historical and predictive insights, creating high-value segments, fueling tools that deliver personalized customer experiences, meeting privacy and compliance standards, and adapting to future evolutions of the tech stack. Amperity’s unique combination of complete profiles, streamlined access, advanced insights, and surprising speed creates the customer data confidence brands need to power meaningful experiences and accelerate growth.

Anagram is the world’s first human-driven security platform that delivers real results. We go beyond traditional methods—like outdated videos and quizzes—by offering phishing simulations and interactive, customizable training designed to engage and educate employees. Our hands-on learning approach and immersive puzzles ensure lasting behavior change, turning your workforce into a proactive line of defense against cyber threats.

Anomaly is streamlining healthcare payments for providers, payers, and patients—reducing healthcare costs and complexity. Over $300B is lost every year to avoidable denials and payment errors, impacting the affordability of healthcare. Anomaly is working with the country’s largest healthcare companies to enable instant, accurate healthcare payments. Our AI-enabled products integrate in the claims flow, analyzing billions of transactions to predict and prevent payment issues before they occur. Smart Response reduces denials and administrative costs by giving providers a real-time response identifying actionable claim errors—so they can avoid denials before the claims even get to the payer. This solution is powered by our claim prediction engine, which predicts with over 99% precision the exact claim line payment and associated denial reason. Instant Pay (coming soon) will further streamline payments by enabling providers to immediately get paid when they submit their claims.

Archon is a biotechnology company developing computationally designed proteins to unlock powerful therapeutic targets that lie beyond the reach of existing modalities and to better treat disease. We directly apply generative protein design to create a new biologic class, Antibody Cages (ABCs), that integrates the industry-proven affinity and specificity of antibodies into self-assembling nanostructures. Precise control over ABC structure provides the ability to tune both how they distribute in the body and engage their cellular targets with high specificity and potency to establish a new gold standard for biologic medicines. Archon Biosciences is based in Seattle and supported by a team of forward-thinking investors led by Madrona Ventures. Our ABC platform was invented with the science and technology recognized by the 2024 Nobel Prize in Chemistry at the Baker Lab in the Institute for Protein Design (IPD).

Archway Software provides a single access point to seamlessly connect any banking platform to third-party financial software providers, with pre-built integrations.

Atomic is an early-stage supply-demand management software startup revolutionizing the way businesses optimize their operations. Our software empowers organizations to efficiently manage their supply chains, streamline demand forecasting, and enhance overall operational efficiency.

Bobsled is a cross-cloud data sharing platform that makes it painless to share data between any data lake or warehouse. We enable product and data teams to share data products directly into a customer or partner’s preferred analytical environment without ever leaving their own.

In 2015, we launched our company with a mission to power the delivery of everything. Since then, we completely reinvented the way vehicles get energy, saving more than eight million miles and four million pounds of CO2 emissions. Booster is energy delivered, integrated logistics, and society’s solution for decarbonizing the last mile.

Branch is the linking and measurement partner for growth-focused teams, trusted to maximize the value of their evolving digital strategies. World-class brands like Instacart, Western Union, NBCUniversal, Zocdoc, and Sephora rely on Branch to acquire users, retain customers, and drive more conversions. Branch has raised more than $667M from investors such as NEA, Founders Fund, and Playground Ventures and is headquartered in Palo Alto, CA, with offices around the globe.

Clari’s revenue platform improves efficiency, predictability, and growth across the entire revenue process. Clari gives revenue teams total visibility into their business, to drive process rigor, spot risk and opportunity in the pipeline, increase forecast accuracy, and drive overall efficiency. Thousands of sales, marketing, and customer success teams at leading companies, including Okta, Adobe, Workday, Zoom, and Finastra, use Clari’s execution insights to make their revenue process more connected, efficient, and predictable. Visit us at clari.com and follow us @clari on LinkedIn.

Clerk is a complete suite of embeddable UIs, flexible APIs, and admin dashboards to authenticate and manage your users.