Invest in your career with a Madrona-funded company.

A-Alpha Bio is a biotechnology company harnessing synthetic biology and machine learning to measure, predict, and engineer protein-protein interactions. Our experimental platform, AlphaSeq, enables the rapid and quantitative measurement of millions of protein-protein binding affinities simultaneously. Our computational platform, AlphaBind, is trained on the world’s largest protein-protein interaction database and predicts binding strength from sequence. A-Alpha Bio leverages AlphaSeq and AlphaBind for in-house therapeutic programs and in partnership with leading pharmaceutical companies to inform the discovery and development of novel therapeutics. A-Alpha Bio is based in Seattle and was founded in 2017 at the University of Washington's Institute for Protein Design and Center for Synthetic Biology. To learn more, please visit: https://www.aalphabio.com/

Amperity is a customer data cloud platform that leverages AI to help businesses build and activate comprehensive customer profiles. By resolving identities and integrating data from various sources, Amperity enables companies to enhance customer engagement, improve marketing performance, and drive loyalty. The platform is designed for ease of use, allowing business users to access insights without heavy coding, and it supports a wide range of industries, including retail and travel. With proven results, such as increased conversion rates and improved return on ad spend, Amperity positions itself as a leader in the customer data management space.

Anagram is the world’s first human-driven security platform that delivers real results. We go beyond traditional methods—like outdated videos and quizzes—by offering phishing simulations and interactive, customizable training designed to engage and educate employees. Our hands-on learning approach and immersive puzzles ensure lasting behavior change, turning your workforce into a proactive line of defense against cyber threats.

Anomaly is streamlining healthcare payments for providers, payers, and patients—reducing healthcare costs and complexity. Over $300B is lost every year to avoidable denials and payment errors, impacting the affordability of healthcare. Anomaly is working with the country’s largest healthcare companies to enable instant, accurate healthcare payments. Our AI-enabled products integrate in the claims flow, analyzing billions of transactions to predict and prevent payment issues before they occur. Smart Response reduces denials and administrative costs by giving providers a real-time response identifying actionable claim errors—so they can avoid denials before the claims even get to the payer. This solution is powered by our claim prediction engine, which predicts with over 99% precision the exact claim line payment and associated denial reason. Instant Pay (coming soon) will further streamline payments by enabling providers to immediately get paid when they submit their claims.

Archon is a biotechnology company developing computationally designed proteins to unlock powerful therapeutic targets that lie beyond the reach of existing modalities and to better treat disease. We directly apply generative protein design to create a new biologic class, Antibody Cages (ABCs), that integrates the industry-proven affinity and specificity of antibodies into self-assembling nanostructures. Precise control over ABC structure provides the ability to tune both how they distribute in the body and engage their cellular targets with high specificity and potency to establish a new gold standard for biologic medicines. Archon Biosciences is based in Seattle and supported by a team of forward-thinking investors led by Madrona Ventures. Our ABC platform was invented with the science and technology recognized by the 2024 Nobel Prize in Chemistry at the Baker Lab in the Institute for Protein Design (IPD).

Archway Software is a fintech company that enables banks and credit unions to digitally transform their services quickly and efficiently. Originating as an innovation lab within Wa Fd Bank, Archway provides a comprehensive digital account opening solution and a mobile banking platform that enhances customer acquisition and retention. Their unique open API architecture allows for seamless integration with existing systems, making it easier for financial institutions to offer superior digital experiences. With a focus on reducing customer acquisition costs and improving customer loyalty, Archway positions itself as a leader in the digital banking space, helping clients grow deposits and enhance customer relationships through data-driven insights.

Atomic is an early-stage supply-demand management software startup revolutionizing the way businesses optimize their operations. Our software empowers organizations to efficiently manage their supply chains, streamline demand forecasting, and enhance overall operational efficiency.

Bobsled is a cross-cloud data sharing platform that makes it painless to share data between any data lake or warehouse. We enable product and data teams to share data products directly into a customer or partner’s preferred analytical environment without ever leaving their own.

In 2015, we launched our company with a mission to power the delivery of everything. Since then, we completely reinvented the way vehicles get energy, saving more than eight million miles and four million pounds of CO2 emissions. Booster is energy delivered, integrated logistics, and society’s solution for decarbonizing the last mile.

Branch is a leading mobile growth and attribution platform that empowers over 100,000 brands, from startups to Fortune 500 companies, to enhance their digital strategies through seamless linking and measurement across devices and channels. Their solutions focus on improving user engagement, optimizing ad performance, and driving conversions, making them a trusted partner in navigating the complexities of the digital landscape. With a strong emphasis on privacy and compliance, Branch differentiates itself by offering advanced tools for deep linking, customer experience, and performance analytics, which collectively contribute to significant growth in mobile revenue and user engagement for their clients.

Clari is a leading revenue operations platform that leverages AI and automation to enhance sales productivity and forecasting accuracy. The platform integrates data from various business systems, providing visibility and predictive insights that help organizations manage their revenue processes more effectively. With capabilities like opportunity management, sales engagement, and conversation intelligence, Clari empowers B2B companies to streamline their revenue operations, reduce churn, and achieve predictable growth. The company serves over 1500 customers, managing a total of $4 trillion in revenue, positioning itself as a key player in the revenue technology space.

Clerk is a comprehensive User Management Platform that offers a suite of embeddable UIs, flexible APIs, and admin dashboards for user authentication and management. It provides features like multifactor authentication, fraud prevention, and session management, making it suitable for fast-growing companies. Clerk differentiates itself with its developer-friendly SDKs and customizable components, allowing seamless integration into various applications. The platform is SOC 2 type 2 certified and CCPA compliant, ensuring high security and privacy standards. With a free tier for up to 10,000 monthly active users, Clerk is positioned to scale with businesses as they grow.