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Scientist I/II, Biophysical Characterization

Nautilus Biotechnology

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San Carlos, CA, USA

Posted on Thursday, April 13, 2023

At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome – one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing deep, hard science with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines.

We are hiring for a Scientist I/II, Biophysical Characterization, to join our growing team. This individual will be tasked with developing and utilizing methods to characterize our affinity reagents and collaborating cross-functionally to incorporate these reagents in the Nautilus platform. This position will work closely with colleagues upstream in the probe development process and downstream in product integration. This is a very team-oriented role, working closely with fellow researchers to design, execute, and analyze experiments.

Responsibilities

You will collaborate with multiple teams performing affinity reagent discovery and screening
You will develop methods to determine whether candidate antibodies and aptamers are likely to succeed within our platform and to better understand specific, off-target, and non-specific binding of affinity reagent candidates
You will generate data on biophysical parameters using multiple platforms such as SPR, BLI, and TIRF
You will routinely present goals and results to various teams within the company
You will work closely with bioinformatics to ensure robust tracking of probe-specific data
You will engage with external partners to drive collaborative activities efficiently

Requirements

A minimum of a PhD, or BS/MS and 8+ years of experience.
Strong expertise in assay development
Background in proteins and affinity reagents
Experience with biophysical characterization such as SPR, BLI, ELISA, ELONA, FRET, etc.
Experience with single molecule methods such as TIRF preferred
Ability to effectively multitask and work in a fast-pace, goal-oriented environment
Highly organized with exquisite attention to detail
Self-motivated, driving projects forward to meet deadlines
Willingness to work collaboratively within a team as well as independently
Excellent written and oral communication skills
Desire to wear multiple hats and be flexible
Strong and effective leader
Agile-like approach to development

Nautilus Team Culture

We are curious go-getters: this is a team of life-long learners who aren’t afraid to tackle the big challenges and we embrace the journey
We are detail oriented: we do great science by working smart & with diligence where we learn from our trials and mistakes
We are easy to work with: we want our workplace to be one where everyone can share their perspective and be treated with respect and kindness

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