Invest in your career with a Madrona-funded company.

At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome – one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing deep, hard science with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines.

We are hiring for a development minded Principal Scientist, Proteomics Applications to join our Applications and Biochemistry teams. This role will work as an intermediary between our collaborative research partners and our R&D teams to ensure that application specific sample preparation workflows and analysis methods are optimized and validated for use in a variety of different study designs. This important work will serve as the foundation of studies that use our platform to investigate interesting biological questions with our external partners and customers. This scientist will need to refine and optimize baseline sample extraction, enrichment, denaturation, functionalization and bio-conjugation workflows against diverse biological targets. Validation and optimization will include the development of appropriate model systems to generate single-molecule protein-DNA conjugate libraries that integrate with the proprietary flow cells within the Nautilus Protein Analysis Platform.