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The hiring pay range for this position is based on skills, education and experience relevant to the role; title may be assessed one level lower or higher, accordingly. Other components of total compensation include a competitive options grant at the time of hire (with potential for additional grants).

Benefits include medical, vision, and dental insurance, group and supplemental life insurance, 401k retirement plan, responsible (unlimited) paid time off, parental leave, and more.

At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome – one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing hard scientific problems with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines.

We are hiring for a Reagent Manufacturing Associate II to join our growing team. This role will oversee the day-to-day production of chemical and biological reagents. This role is responsible for ensuring the efficient, compliant, and high-quality manufacturing of reagents used in [e.g., diagnostic assays, research products, clinical applications]. The ideal candidate will have strong project leadership skills, deep knowledge of reagent formulation and production processes, and experience working in a regulated laboratory or manufacturing environment. Candidate should be comfortable working both independently on routine tasks and collaboratively on more complex operations, escalating issues as appropriate.

Responsibilities

• Perform and coordinate reagent production activities with minimal guidance to meet operational goals, batch schedules, and quality standards.

• Ensure manufacturing processes are executed according to SOPs, batch records, and regulatory guidelines (e.g., ISO 13485, GMP).

• Perform reagent formulation, antibody conjugation/purification, buffer preparation, mixing, filtration, filling, and labeling operations.

• Collaborate with Quality Control, R&D, and Supply Chain to troubleshoot issues and optimize workflows.

• Maintain accurate production documentation and ensure traceability and compliance with documentation practices.

• Operate HPLC systems, Small-scale TFF benchtop systems, Tangential Flow Filtration Systems, Automated Liquid Handling systems, process troubleshooting, and data analysis.

• Monitor inventory levels of raw materials and coordinate with procurement for replenishment.

• Support continuous improvement initiatives, including process optimization and cost reduction.

• Train junior team members on equipment, procedures, and safety protocols.

• Ensure cleanliness, maintenance, and calibration of manufacturing equipment.

• Investigate and document deviations, non-conformances, and participate in root cause analysis and CAPA implementation.

Qualifications

• Bachelor’s degree in Chemistry, Biochemistry, Biotechnology, or related field (or equivalent experience).

• 3–5 years of experience in reagent or chemical manufacturing, preferably in a regulated environment.

• Strong knowledge of GMP, ISO 13485, or other relevant quality systems.

• Excellent organizational, communication, and interpersonal skills.

• Self-motivated, adaptable to shifting priorities, and comfortable in a fast-paced, small-company environment.

• Knowledge of systems such as HPLC, Small-scale TFF benchtop systems, Tangential Flow Filtration Systems, Automated Liquid Handling systems, Benchling, and electronic batch records is a plus.

Preferred Qualifications

• Experience in manufacturing reagents for diagnostic or life sciences applications.

• Familiarity with ERP or MES systems (e.g., Oracle, NetSuite) and LIMS systems.

• Lean manufacturing or Six Sigma training/certification.

Work Environment

• Laboratory and manufacturing setting with potential exposure to chemicals and biological materials.

• Requires use of PPE and adherence to safety protocols.

• May involve occasional lifting (up to 50 lbs), standing for long periods, and working in cold rooms or cleanroom environments.

Nautilus Team Culture

• We are determined to do whatever it takes to get our platform into the hands of researchers who will use it to upend the status quo in basic research and healthcare.

• We work on cross functional teams, wear many hats, take risks to work through uncertainty, enjoy working collaboratively on challenging problems, and celebrate one another’s victories.

• We go above and beyond, but also strive to provide a supportive atmosphere of colleagues who are willing to lend a helping hand and make working at Nautilus not only fulfilling in its end goals, but enjoyable on a day-to-day basis.

Compensation Range: $57K - $86K