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The hiring pay range for this position is based on skills, education, and experience relevant to the role. New hires are typically hired into the low to midpoint of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. Pay ranges are adjusted based on cost of labor in each respective geographical market. Your recruiter can share more about the specific pay range for your location during the hiring process.

Benefits include medical, vision, and dental insurance, group and supplemental life insurance, 401k retirement plan, responsible paid time off, parental leave, and more. Other components of total compensation include a competitive options grant at the time of hire (with potential for additional grants).

At Nautilus, we have a big and important mission: improve the health of millions by unleashing the potential of the proteome to accelerate drug development and enable a new world of precision and personalized medicine. We are developing a single-molecule protein analysis platform of unprecedented sensitivity, scale, and ease of use that we believe will democratize access to the proteome – one of the most dynamic and valuable sources of biological insight. To accomplish this, we are pursuing hard scientific problems with an entrepreneurial mindset and creating a world-class team of builders, innovators, and dreamers across a wide range of disciplines.

We are seeking a Scientist I who is passionate about discovery and innovation to join our Assay Development Team. This role sits at the intersection of science, engineering, and operations, supporting the development of cutting-edge single-molecule proteomics technologies. We’re looking for a curious, collaborative teammate who is eager to grow, work across disciplines, and contribute to impactful scientific work. In this role, you will design and execute complex experiments, analyze multidimensional data, and help advance our platform through thoughtful, hands-on science.

Responsibilities

• Design and develop simple and robust assays/reagents with a holistic understanding of the Nautilus proteomics platform and customer needs.

• Plan and execute complex, information-rich experiments to guide assay development and platform innovation.

• Optimize and perform protein extraction and nano-particle conjugation for single-molecule analysis using a variety of biological samples from collaborators and customers.

• Develop and refine strategies for protein and nucleic acid labeling, surface passivation, and characterization to support advances in single-molecule imaging.

• Maintain precise and timely documentation of experimental results; communicate findings clearly in both written and oral formats to colleagues and stakeholders

Requirements

• PhD in Biochemistry, Biophysics, Chemical Biology, or a related discipline and relevant industry experience; or BS/MS with substantial relevant industry experience.

• Demonstrated hands-on experience in assay development, bioconjugation, biosensors, and/or single-molecule spectroscopy.

• Experience working with complex or prototype instrumentation is a strong plus.

• Proven ability to contribute to interdisciplinary, cross-functional research and deliver results in a fast-paced, dynamic environment.

• Strong organizational skills in documentation, communication, and collaboration.

Compensation Range: $111K - $162K